School of Medicine - Clinical MedicineDiabetology and Endocrinology




Our laboratory is aiming to elucidate the mechanism of diabetic complications, in particular, diabetic nephropathy, and develop a novel therapy for diabetic nephropathy. Our main research themes are as follows: Elucidation of the mechanism of renal fibrosis in diabetic condition, Research on the effectiveness for DPP4 inhibitors and endogenous anti-fibrotic peptide AcSDKP for diabetes-induced renal fibrosis, Study on the renal protective effect through the maintenance of mitochondrial homeostasis or the activation of autophagy by calorie restriction or low-protein diet protein, Elucidation of neural regulatory mechanism for insulin secretion by GLP-1. Clinically, we are focusing on the prevention of the severity of diabetes and diabetic complication by way of team medical care. In addition, we are performing significant clinical research to elucidate the effectiveness for diabetes and diabetic nephropathy of the medicines for diabetes such as DPP4 inhibitors and SGLT2 inhibitors.

Contact Information

TEL: 076(286)2211(ex.3305) +81-76-286-2211  / FAX: 076(286)6927(ex.8927) +81-76-286-6927 / Email:


Professor and Chair

  • KOYA Daisuke 内分泌内科学3古家

Associate Professor

  • NAKAGAWA Atsushi
  • KANASAKI Keizo
  • KITADA Munehiro

Senior Assistant Professor

  • KONISHI Kazunori

Assistant Professor

  • NITTA Kyoko

Research Doctor

  • OGURA Yoshio
  • TAKAGI Shin
  • SHIMADA Keiji
  • MIZUNUMA Yuiko
  • MONNO Itaru
  • FUJII Ai

Research Achievements

Research Activities

  • M.Kitada, Y.Ogura, T.Suzuki, S.Shi, S.M.Lee, K.Kanasaki, S.Kume, D.Koya: A very-low-protein diet ameliorates advanced diabetic nephropathy through autophagy induction by suppression of the mTORC1 pathway in wistar fatty rats, an animal model of type 2 diabetes and obesity., Diabetologia, 59:1307-1317, 2016
  • K.Nitta, S.Shi, T.Nagai, M.Kanasaki, M.Kitada, S.P.Srivastava, M.Haneda, K.Kanasaki, D.Koya : Oral administration of N-acetyl-seryl-aspartyl-lysyl-proline ameliorates kidney disease in both type 1 and type 2 diabetic mice via a therapeutic regimen., Biomed Res. Int., 2016:9172157-9172157, 2016.
  • S.P.Srivastava, S.Shi, M.Kanasaki, T.Nagai, M.Kitada, J.He, Y.Nakamura, Y.Ishigaki, K.Kanasaki, D.Koya : Effect of Antifibrotic microRNAs crosstalk on the action of N-acetyl-seryl-aspartyl-lysyl-proline in diabetes-related kidney fibrosis., Sci. Rep., 6:29884-29884, 2016.
  • M.Kitada, Y.Ogura, D.Koya : The protective role of Sirt1 in vascular tissue: its relationship to vascular aging and atherosclerosis., Aging(Albany NY), 8:2290-2307 , 2016.
  • S.Shi, K.Kanasaki, D.Koya : Linagliptin but not sitagliptin inhibited transforming growth factor-β2-induced endothelial DPP-4 activity and the endothelial-mesenchymal transition., Biochemi. Biophys. Res. Commun., 471:184-190, 2016.

External Research Funding

  • Grant-in-Aid for Exploratory Research, Daisuke Koya, 2016-2018
  • Grant-in-Aid for Scientific Research(C), Munehiro Kitada, 2017-2019
  • Grant-in-Aid for Young Scientists,Yoshio Ogura,2017-2019