School of Medicine - Clinical MedicineDiabetology and Endocrinology




Our laboratory is aiming to elucidate the mechanism of diabetic complications, in particular, diabetic nephropathy, and develop a novel therapy for diabetic nephropathy. Our main research themes are as follows: Elucidation of the mechanism of renal fibrosis in diabetic condition, Research on the effectiveness for DPP4 inhibitors and endogenous anti-fibrotic peptide AcSDKP for diabetes-induced renal fibrosis, Study on the renal protective effect through the maintenance of mitochondrial homeostasis or the activation of autophagy by calorie restriction or low-protein diet protein, Elucidation of neural regulatory mechanism for insulin secretion by GLP-1. Clinically, we are focusing on the prevention of the severity of diabetes and diabetic complication by way of team medical care. In addition, we are performing significant clinical research to elucidate the effectiveness for diabetes and diabetic nephropathy of the medicines for diabetes such as DPP4 inhibitors and SGLT2 inhibitors.

Contact Information

TEL: 076(286)2211(ex.3305) +81-76-286-2211  / FAX: 076(286)6927(ex.8927) +81-76-286-6927 / Email:


Professor and Chair

  • KOYA Daisuke 内分泌内科学3古家

Visiting Professor

  • TERADA Masahiko
  • KANASAKI Keizo


  • NAKAGAWA Atsushi

Associate Professor

  • KITADA Munehiro
  • KONISHI Kazunori

Assistant Professor

  • OGURA Yoshio
  • SHIMADA Keiji
  • HIRAI Taro

Assistant Professtor

  • MONNO Itaru

Research Doctor

  • HAYASHI Yoshihiro

Research Achievements

Research Activities

  • A low-protein diet for diabetic kidney disease: its effect and molecular mechanism, an approach from animal studies: Munehiro.Kitada, Yoshio.Ogura, Itaru.Monno, Daisuke.Koya, 10(5). pii: E544. doi: 10.3390/nu10050544., 2018
  • Renal mitochondrial oxidative stress is enhanced by the reduction of Sirt3 activity, in Zucker diabetic fatty rats: Yoshio.Ogura, Munehiro.Kitada, Itaru.Monno, Keizo,Kanasaki, Ai.Watanabe, Daisuke.Koya, Redox Report: CommuniCations in Free Radical Research, 23(1):153-159, 2018
  • FGFR1 is essential for N-acetyl-seryl-aspartyl-lysyl-proline regulation of mitochondrial dynamics by upregulating microRNA let-7b-5p: Qiongying.Hu, Jinpeng.Li, Kyoko.Nitta, Munehiro.Kitada, Takako.Nagai, Keizo.Kanasaki, Daisuke.Koya, Biochemical and Biophysical Research Communications, 495(3):2214-2220, 2018
  • A low-protein diet exerts a beneficial effect on diabetic status and prevents diabetic nephropathy in Wistar fatty rats, an animal model of type 2 diabetes and obesity: Munehiro.Kitada, Yoshio.Ogura, Taeko.Suzuki, Itaru.Monno, Keizo.Kanasaki, Ai.Watanabe, Daisuke.Koya, Nutrition & Metabolism, 15:20.doi: 10.1186/s12986-018-0255-1. eCollection 2108., 2018
  • A ketogenic amino acid rich diet benefits mitochondrial homeostasis by altering the AKT/4EBP1 and autophagy signaling pathways in the gastrocnemius and soleus: Jinpeng.Li, Megumi.Kanasaki, Ling.Xu , Munehiro.Kitada, Kenji.Nagao, Yusuke.Adachi, Hiroko.Jinzu, Yasushi.Noguchi, Miyuki.Kohno, Keizo.Kanasaki, Daisuke.Koya, Biochimica et Biophysica Acta General Subject, 1862(7):1547-1555, 2018

External Research Funding

  • Grant-in-Aid for Scientific Research(C), Munehiro Kitada, 2017-2019
  • Grant-in-Aid for Young Scientists,Yoshio Ogura,2017-2019
  • Grant-in-Aid for Young Scientists, Yuta Takagaki, 2018-2020
  • Grant-in-Aid for Young Scientists, Itaru Monno, 2018-2020
  • Grant-in-Aid for Young Scientists, Taro Hirai, 2019-2022