School of Medicine - Clinical MedicineDiabetology and Endocrinology




Our laboratory is aiming to elucidate the mechanism of diabetic complications, in particular, diabetic nephropathy, and develop a novel therapy for diabetic nephropathy. Our main research themes are as follows: Elucidation of the mechanism of renal fibrosis in diabetic condition, Research on the effectiveness for DPP4 inhibitors and endogenous anti-fibrotic peptide AcSDKP for diabetes-induced renal fibrosis, Study on the renal protective effect through the maintenance of mitochondrial homeostasis or the activation of autophagy by calorie restriction or low-protein diet protein, Elucidation of neural regulatory mechanism for insulin secretion by GLP-1. Clinically, we are focusing on the prevention of the severity of diabetes and diabetic complication by way of team medical care. In addition, we are performing significant clinical research to elucidate the effectiveness for diabetes and diabetic nephropathy of the medicines for diabetes such as DPP4 inhibitors and SGLT2 inhibitors.

Contact Information

TEL: 076(286)2211(ex.3305) +81-76-286-2211  / FAX: 076(286)6927(ex.8927) +81-76-286-6927 / Email:


Professor and Chair

  • KOYA Daisuke 内分泌内科学3古家

Associate Professor

  • NAKAGAWA Atsushi
  • KANASAKI Keizo
  • KITADA Munehiro
  • KONISHI Kazunori

Assistant Professor

  • NITTA Kyoko
  • OGURA Yoshio
  • SHIMADA Keiji

Research Doctor

  • HIRAI Taro
  • MIZUNUMA Yuiko
  • MONNO Itaru

Research Achievements

Research Activities

  • M.Kitada, Y.Ogura, T.Suzuki, I.Monno, K.Kanasaki, A.Watanabe, D.Koya: Cyclic and intermittent very low-protein diet can have beneficial effects against advanced diabetic nephropathy in Wistar fatty (fa/fa) rats, an animal model of type 2 diabetes and obesity, NEPHROLOGY, 22:1030-1034, 2017.
  • M.Kitada, Y.Ogura, H.Maruki-Uchida, M.Sai, T.Suzuki, K.Kanasaki, Y.Hara, H.Seto, Y.Kuroshima, I.Monno, D.Koya: The Effect of Piceatannol from Passion Fruit (Passiflora edulis) Seeds on Metabolic Health in Humans, NUTRIENTS, 9:10.3390/nu9101142, 2017.
  • J.Li, S.Shi, S.P.Srivastava, M.Kitada, T.Nagai, K.Nitta, M.Kohno, K.Kanasaki, D.Koya: FGFR1 is critical for the anti-endothelial mesenchymal transition effect of N-acetyl-seryl-aspartyl-lysyl-proline via induction of the MAP4K4 pathway, CELL DEATH & DISEASE, 8:10.1038/cddis.2017.353, 2017.
  • M.Kitada, Y.Ogura, I.Monno, D.Koya : Regulating Autophagy as a Therapeutic Target for Diabetic Nephropathy., Current diabetes reports, 17:10.1007/s11892-017-0879-y, 2017.
  • M.Kitada, S.Tsuda, K.Konishi, A.Takeda-Watanabe, M.Fujii, K.Kanasaki, M.Nishizawa, A.Nakagawa, D.Koya,: Anagliptin ameliorates albuminuria and urinary liver-type fatty acid-binding protein excretion in patients with type 2 diabetes with nephropathy in a glucose-lowering-independent manner., BMJ open diabetes research & care, 5:10.1136/bmjdrc-2017-000391, 2017.

External Research Funding

  • Grant-in-Aid for Exploratory Research, Daisuke Koya, 2016-2018
  • Grant-in-Aid for Scientific Research(C), Munehiro Kitada, 2017-2019
  • Grant-in-Aid for Young Scientists,Yoshio Ogura,2017-2019
  • Grant-in-Aid for Young Scientists, Yuta Takagaki, 2018-2020
  • Grant-in-Aid for Young Scientists, Itaru Monno, 2018-2020